Anticonvulsant and Convulsant effects of Indole derivatives against Chemical Models of Epilepsy

Indole is a benzopyrrole in which the benzene and pyrrole rings are fused through the 2-and 3-positions of the pyrrole nucleus. The indole derivatives are very much used as anticonvulsant agents. In the same context, several indole derivatives were prepared by the reaction between indole-3carboxaldehyde and various p-substituted phenylsemicarbazides, in the presence of glacial acetic acid. The Mannich bases of above synthesized compounds were prepared by using formaldehyde & various secondary amines. All the prepared derivatives were screened against different chemical induced convulsion models such as isoniazid, thiosemicarbazide & 4-aminopyridine respectively, for their possible convulsant and anticonvulsant activity. The derivatives were also evaluated for their sedativehypnotic properties using phenobarbitone induced sleeping model & also for their neurotoxicity. The result showed that some of the compounds were very much active against different convulsant models, proving their different mode of actions in the course of epileptic seizures.